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CENFORCE 150mg contains Sildenafil Citrate as a therapeutic entity. It is prescribed for erectile dysfunction (ED) in males which regarded as the inability to achieve and maintain erection during physical intercourse. Sildenafil selectively inhibits cyclic guanosine monophosphate (cGMP)-specific Phosphodiesterase-5 (PDE5).

Quantity Strength Price Unit Price
40 Tablets Cenforce 150 - Generic Sildenafil Citrate 150mg $34.00 $0.85
60 Tablets Cenforce 150 - Generic Sildenafil Citrate 150mg $48.00 $0.80
100 Tablets Cenforce 150 - Generic Sildenafil Citrate 150mg $75.00 $0.75

CENFORCE 150mg is an oral therapy for dealing with impotence in males. It is used for treating erectile dysfunction (ED) in males. It contains sildenafil citrate which inhibits Phosphodiesterase 5 (PDE 5) resulting in manifestation of action of cGMP which causes erection during sexual stimulation. It does not act as aphrodisiac; It requires an external stimuli to act.  Sildenafil is the first medicine launched by Pfizer as a treatment of erectile dysfunction. It does not cure the main cause of ED.

MECHANISM OF ACTION
 cGMP causes relaxation of vascular smooth muscles and augment blood flow to various body tissues.  PDE5 (phosphodiesterase5) is an enzyme which degrades cGMP thereby inhibiting its action. It is found in the walls of penile blood vessels, erectile tissue of the penis and retina of the eye. Sildenafil enhances the activity and concentration of cGMP in tissues by blocking PDE5. Increased cGMP causes widening of blood vessels of the penis resulting in erection.

 INDICATIONS AND USES

Sildenafil Citrate is primarily employed for erectile dysfunction (impotence) in men. It is also an effective medicine for pulmonary arterial hypertension.
Sildenafil Citrate may also be used for other purposes other than that mentioned here.

DOSAGE AND ADMINISTRATION

CENFORCE is intended to be taken by mouth only with a glass full of water.  One pill should be taken about 30 minutes preceding intercourse. Its effect lasts for 4 hours. Discuss with your doctor before using it; follow the dosage regimen prescribed by your doctor. Do not take it more than once a day. Maintain a dosing interval of 24 hours. Use of grapefruit juice and meals rich in fats must be avoided with CENFORCE. They delay the action and enhance side effects of CENFORCE.

Missed doses:  

Cenforce 150mg is used when required, so chance of missed doses is unlikely.

Overdose:

If case of overdosing, seek emergency medical treatment right away. The symptoms appear as a result of overdose are pain in the chest, irregular heartbeat, vomiting, severe drowsiness, fainting.

SIDE EFFECTS

Side effects are Headache, dizziness, Flushing, pain in the back and legs, blocked nose, Visual deformity or blurred vision, sudden decline in hearing ability, ringing in ears, rashes on the body, diarrhoea, nausea, vomiting, erection that is painful and lasts for more than 4 hours. You can also observe some side effects other than that mentioned here. If you experience any unwanted effect immediately consult your physician.                       

CONTRAINDICATIONS

1. It should not be used in patients with a history of hypersensitivity or allergy to Sildenafil or any of the other components of CENFORCE.
2. Simultaneous use of CENFORCE and nitrate containing drugs is highly contraindicated. It can lead to the accentuation of the blood pressure lowering effect of both.
3. Cenforce is not recommended for use in women and individuals under 18 years.
4. Use of CENFORCE is contraindicated in patients with severe liver and kidney dysfunction.
5. Patient with history (past 6 months) of ischemic heart disease, myocardial infarction, angina arrhythmia, stroke and optic neuropathy should use CENFORCE only with the advice of doctor.

WARNINGS/PRECAUTIONS

1. Always consult your doctor prior to taking CENFORCE if you are facing serious medical illness.
2. Significant alcohol consumption should be avoided with this drug. It can cause light-headedness, lowering of blood pressure, fainting.
3. In patient with significant heart disease, sexual activity is associated with potential cardiac risk. So, in this case CENFORCE be used only under doctor’s supervision.
4. Caution is advised during concomitant use of alpha blocking agents and Cenforce; it may result in severe decline blood pressure.
5. Patients with penis deformation or blood disorders like sickle cell anaemia, multiple myeloma should consult doctor before using CENFORCE.
6. Do not consume grapefruit juice and fat rich diet with CENFORCE.


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